SANTA CLARA, Calif. (KRON) — The injury bug has hit the San Francisco 49ers again. Star wide receiver Deebo Samuel was carted off the field in the second quarter of Sunday’s home game against the Tampa Bay Buccaneers.

The 49ers initially said Samuel suffered a knee injury and was questionable to return, according to KRON4’s Kate Rooney. However, the team is now saying it’s an ankle injury, and Samuel will be out for the rest of this game.

Head coach Kyle Shanahan says Samuel’s injury is “most likely” a high-ankle sprain. The recovery time for that injury would typically be four to six weeks, but the 49ers have not officially announced a timetable for Samuel’s return.

The injury happened after a 3-yard rushing attempt by Samuel who also fumbled the ball. Samuel appeared to be sandwiched by multiple Bucs players.

Samuel’s injury comes one week after 49ers quarterback Jimmy Garoppolo suffered a foot injury against the Miami Dolphins. Garoppolo will be out for at least the remainder of the regular season.

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The 49ers won 35-7 to move to 9-4 and stay atop the NFC West standings. They have a short week and will travel to Seattle to take on the Seahawks Thursday night.

This is a developing story. Check back for updates as KRON4 learns more.